Hi Guys, I don't have much experience in the realm of pain medications and I wanted some input from you guys on how effective Tylenol with Codeine 3 (300-30) is. For joint pain relief, try TYLENOL® 8HR Arthritis Pain. Its bi-layer design first dissolves fast, then lasts up to 8 hrs. Available as caplets. Its bi-layer design first dissolves fast, then lasts up to 8 hrs. Codeine is an opioid pain medication, sometimes called a narcotic. Acetaminophen is a less potent pain reliever that increases the effects of codeine. Codeine is a narcotic pain reliever (analgesic) used to treat mild to moderately severe pain. It is frequently combined with Tylenol or aspirin for more effective pain relief. Common side effects include itching, rash, stomach pain, constipation, shortness of breath, nausea, lightheadedness, and dizziness. Codeine is an opioid pain medication. Acetaminophen is a less potent pain reliever that increases the effects of codeine. Tylenol with Codeine 3 is a combination medicine used to relieve moderate to severe pain. REST + RELIEF. Take a pain reliever like TYLENOL® (Use as directed) and avoid strenuous activity. Often prescribed for neck and back pain after OTC drugs like acetaminophen. doses instead. You can contact your doctor for more later if you find you need the rest of the typical course, and having. Codeine works in the brain to change how your body feels and responds to pain. Acetaminophen can also reduce a fever. Acetaminophen can also reduce a fever. How to use Tylenol-Codeine NO.3 Caregivers or others need to get medical help right away if the patient does not respond, does not answer or react like normal, or will not wake up. Using Tylenol w/ Codeine (acetaminophen and codeine tablets) for a long time during pregnancy may lead to withdrawal in the newborn baby. I am in a lot of pain. I was prescribed Tylenol with Codeine,1- 2 tablets every 4-6 hours or Vicodin 1-2 tablets every 6 hours. The Vicodin is stronger, but wears off after 3 1/2-4 hours.